at UC San Diego
Publications
Placental pathology and fetal growth outcomes in pregnancies complicated by maternal obesity
Samantha Hietalati, Donna Pham, Harneet Arora, Marina Mochizuki, Gisselle Santiago, Jordan Vaught, Erika T Lin, Karen K Mestan, Mana Parast, Marni B Jacobs
Int J Obes (Lond)​; 2024 Sep;48(9):1248-1257.
doi: 10.1038/s41366-024-01546-y.
PMID: 38822073
Universal Digital High-Resolution Melt Analysis for the Diagnosis of Bacteremia
April Aralar, Tyler Goshia, Nanda Ramchandar, Shelley M Lawrence, Aparajita Karmakar, Ankit Sharma, Mridu Sinha, David T Pride, Peiting Kuo, Khrissa Lecrone, Megan Chiu, Karen K Mestan, Eniko Sajti, Michelle Vanderpool, Sarah Lazar, Melanie Crabtree, Yordanos Tesfai, Stephanie I Fraley
J Mol Diagn​. 2024 May;26(5):349-363
PMID: 38395408​
Cord Blood Adductomics Reveals Oxidative Stress Exposure Pathways of Bronchopulmonary Dysplasia
Erika T. Lin, Yeunook Bae, Robert Birkett, Abhineet M. Sharma, Runze Zhang, Kathleen M. Fisch, William Funk and Karen K. Mestan
Antioxidants. 2024 April 20; 13(4), 494.
PMID: 38671941
Maternal-Fetal Connections in Prenatal Respiratory Disease: Time to Address Intrauterine Inflammation
Karen K Mestan, Abhineet Sharma, Sarah Lazar, Sonalisa Pandey, Mana M Parast, Louise C Laurent, Lawrence S Prince, Debashis Sahoo
Am J Respir Crit Care Med​. 2024 Mar 15;209(6):621-622
PMID: 38352616​
Bilateral Renal Agenesis-Interpreting the RAFT Trial
Cynthia Gyamfi-Bannerman, Krishelle Marc-Aurele, Karen Mestan
JAMA​. 2023 Dec 5;330(21):2059-2060
PMID: 38051335
Development of a novel humanized mouse model to study bronchopulmonary dysplasia
Birkett R, Newar J, Sharma AM, Lin E, Blank L, Swaminathan S, Misharin A, Mestan KK. Development of a novel humanized mouse model to study bronchopulmonary dysplasia. Front Pediatr. 2023 Jul 14;11:1146014.
doi: 10.3389/fped.2023.1146014.
PMID: 37520051
Leveraging the placenta to advance neonatal care
Mestan KK, Leibel SL, Sajti E, Pham B, Hietalati S, Laurent L and Parast M
Front. Pediatr. 2023 May; 11:1174174.
https://doi.org/10.3389/fped.2023.1174174
PMID: 37255571
Placental dysfunction influences fetal monocyte subpopulation gene expression in preterm birth
Sharma AM, Birkett R, Lin ET, Ernst LM, Grobman WA, Swaminathan S, Abdala-Valencia H, Misharin AV, Bartom ET, Mestan KK
JCI Insight. 2022 Jun; 7(11):
https://doi.org/10.1172/jci.insight.155482
PMID: 35471950
Moving the dial on prenatal stress mechanisms of neurodevelopmental vulnerability to mental health problems: A personalized prevention proof of concept
Wakschlag LS, Tandon D, Krogh-Jespersen S, Petitclerc A, Nielsen A, Ghaffari R, Mithal L, Bass M, Ward E, Berken J, Fareedi E, Cummings P, Mestan K, Norton ES, Grobman W, Rogers J, Moskowitz J, Alshurafa N
Dev Psychobiol. 2021 May; 63(4): 622-640.
https://doi.org/10.1002/dev.22057
PMID: 33225463
Understanding Racial Disparities of Preterm Birth Through the Placenta
Matoba N, Mestan KK, Collins JW
Clin Ther. 2021 Feb; 43(2): 287-296.
https://doi.org/10.1016/j.clinthera.2020.12.013
PMID: 33483135
Umbilical cord miRNAs to predict neonatal early onset sepsis
Ernst LM, Mithal LB, Mestan K, Wang V, Mangold KA, Freedman A, Das S
PLoS One. 2021; 16(5): e0249548-.
https://doi.org/10.1371/journal.pone.0249548
PMID: 33961620
Placental vascular maldevelopment, intrauterine growth restriction, and pulmonary hypertension
Mathias M, Bitar M, Aldulescu M, Birkett R, Perez M, Mestan K
Pulm Circ. 2020 Oct; 10(4): 2045894020970056-.
https://doi.org/10.1177/2045894020970056
PMID: 33282199 ISSN: 2045-8932
Soluble Klotho, a biomarker and therapeutic strategy to reduce bronchopulmonary dysplasia and pulmonary hypertension in preterm infants
Batlahally S, Franklin A, Damianos A, Huang J, Chen P, Sharma M, Duara J, Keerthy D, Zambrano R, Shehadeh LA, Martinez EC, DeFreitas MJ, Kulandavelu S, Abitbol CL, Freundlich M, Kanashiro-Takeuchi RM, Schmidt A, Benny M, Wu S, Mestan KK, Young KC
Sci Rep. 2020 Jul; 10(1): 12368-.
https://doi.org/10.1038/s41598-020-69296-1
PMID: 32704023
The impact of placental pathology discordance in multiple gestation pregnancies on bronchopulmonary dysplasia-associated pulmonary hypertension
Franklin A, Yallapragada S, Birkett R, Grobman W, Ernst LM, Mestan K
Pulm Circ. 2020 Jan; 10(1): 2045894020910674-.
https://doi.org/10.1177/2045894020910674
PMID: 32215199 ISSN: 2045-8932
Cord blood alpha klotho is decreased in small for gestational age preterm infants with placental lesions of accelerated aging
Franklin AD, Saqibuddin J, Stephens K, Birkett R, Marsden L, Ernst LM, Mestan KK
Placenta. 2019 Nov; 87: 1-7.
https://doi.org/10.1016/j.placenta.2019.08.088
PMID: 31499336
Racial differences in placental pathology
among very preterm births
Matoba N, Yallapragada S, Davis MM, Ernst LM, Collins JW, Mestan KK
Placenta. 2019 Aug; 83: 37-42.
https://doi.org/10.1016/j.placenta.2019.06.385
PMID: 31477205
Variations in Umbilical Cord Hematopoietic
and Mesenchymal Stem Cells
With Bronchopulmonary Dysplasia
Chaudhury S, Saqibuddin J, Birkett R, Falcon-Girard K, Kraus M, Ernst LM, Grobman W, Mestan KK
Front Pediatr. 2019; 7: 475-.
https://doi.org/10.3389/fped.2019.00475
PMID: 31799226 ISSN: 2296-2360
An update on the diagnosis and management
of bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension
Berkelhamer SK, Mestan KK, Steinhorn R
Semin Perinatol. 2018 Nov; 42(7): 432-443.
https://doi.org/10.1053/j.semperi.2018.09.005
PMID: 30384985
Umbilical cord blood metabolomics reveal distinct signatures of dyslipidemia prior to bronchopulmonary dysplasia and
pulmonary hypertension
La Frano MR, Fahrmann JF, Grapov D, Pedersen TL, Newman JW, Fiehn O, Underwood MA, Mestan K, Steinhorn RH, Wedgwood S
Am J Physiol Lung Cell Mol Physiol. 2018 Nov; 315(5): L870-L881.
https://doi.org/10.1152/ajplung.00283.2017
PMID: 30113229
Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy
Liu X, Hong X, Tsai H-J, Mestan KK, Shi M, Kefi A, Hao K, Chen Q, Wang G, Caruso D, Geng H, Gao Y, He J, Kumar R, Wang H, Yu Y, Bartell T, Tan X-D, Schleimer RP, Weeks DE, Pongracic JA, Wang X
Medicine (Baltimore). 2018 Mar; 97(9): e0043-.
https://doi.org/10.1097/MD.0000000000010043
PMID: 29489655
Vital signs analysis algorithm detects inflammatory response in premature infants with late onset sepsis and necrotizing enterocolitis
Mithal LB, Yogev R, Palac HL, Kaminsky D, Gur I, Mestan KK
Early Hum Dev. 2018 Feb; 117: 83-89.
https://doi.org/10.1016/j.earlhumdev.2018.01.008
PMID: 29351876
Fetal cord blood and tissue immune responses to chronic placental inflammation
and chorioamnionitis
Singh AM, Sherenian MG, Kim K-Y, Erickson KA, Yang A, Mestan K, Ernst LM, Kumar R
Allergy Asthma Clin Immunol. 2018; 14: 66-.
https://doi.org/10.1186/s13223-018-0297-y
PMID: 30473713 ISSN: 1710-1484
Cord Blood Biomarkers of Placental Maternal Vascular Underperfusion Predict Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension
Mestan KK, Gotteiner N, Porta N, Grobman W, Su EJ, Ernst LM
J Pediatr. 2017 Jun; 185: 33-41.
https://doi.org/10.1016/j.jpeds.2017.01.015
PMID: 28162769
Cord Blood Acute Phase Reactants Predict Early Onset Neonatal Sepsis in Preterm Infants
Mithal LB, Palac HL, Yogev R, Ernst LM, Mestan KK
PLoS One. 2017; 12(1): e0168677-.
https://doi.org/10.1371/journal.pone.0168677
PMID: 28045978
Computerized vital signs analysis and late onset infections in extremely low gestational age infants
Mithal LB, Yogev R, Palac H, Gur I, Mestan KK
J Perinat Med. 2016 Jul; 44(5): 491-497.
https://doi.org/10.1515/jpm-2015-0362
PMID: 26845716
Cord Blood Ferritin and Fibroblast Growth Factor-23 Levels in Neonates
Ali FN, Josefson J, Mendez AJ, Mestan K, Wolf M
J Clin Endocrinol Metab. 2016 Apr; 101(4): 1673-1679.
https://doi.org/10.1210/jc.2015-3709
PMID: 26859104
The placenta as a diagnostic tool
for the neonatologist
Yallapragada SG, Mestan KK, Ernst LM
NeoReviews. 2016 Mar; 17(3): e131-e143.
Placental Villous Vascularity Is Decreased in Premature Infants with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension
Yallapragada SG, Mestan KK, Palac H, Porta N, Gotteiner N, Hamvas A, Grobman W, Ernst LM
Pediatr Dev Pathol. 2016 Mar; 19(2): 101-107.
https://doi.org/10.2350/15-05-1646-OA.1
PMID: 26366786 ISSN: 1093-5266
Flow Cytometry Reveals Similarities
Between Lung Macrophages in Humans and Mice
Bharat A, Bhorade SM, Morales-Nebreda L, McQuattie-Pimentel AC, Soberanes S, Ridge K, DeCamp MM, Mestan KK, Perlman H, Budinger GRS, Misharin AV
Am J Respir Cell Mol Biol. 2016 Jan; 54(1): 147-149.
https://doi.org/10.1165/rcmb.2015-0147LE
PMID: 26274047
Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARNT)
Su EJ, Xin H, Yin P, Dyson M, Coon J, Farrow KN, Mestan KK, Ernst LM
Journal of Clinical Endocrinology and Metabolism. 2015 Jan; 100(1): E30-E40.
https://doi.org/10.1210/jc.2014-2385
PMID: 25343232 ISSN: 0021-972X
Response to "Letter to the editor: Angiogenesis factors in cord blood and post-natal growth failure: a biochemical evaluation"
Baehl Voller S, Mestan KK
Early Hum Dev. 2014 Sep; 90(9): 543-.
https://doi.org/10.1016/j.earlhumdev.2014.05.012
PMID: 24954697
Placental pathologic changes of maternal vascular underperfusion in bronchopulmonary dysplasia and pulmonary hypertension
Mestan KK, Check J, Minturn L, Yallapragada S, Farrow KN, Liu X, Su E, Porta N, Gotteiner N, Ernst LM
Placenta. 2014 Aug; 35(8): 570-574.
https://doi.org/10.1016/j.placenta.2014.05.003
PMID: 24906549
Maternal preconception body mass index and offspring cord blood DNA methylation: exploration of early life origins of disease
Liu X, Chen Q, Tsai H-J, Wang G, Hong X, Zhou Y, Zhang C, Liu C, Liu R, Wang H, Zhang S, Yu Y, Mestan KK, Pearson C, Otlans P, Zuckerman B, Wang X
Environ Mol Mutagen. 2014 Apr; 55(3): 223-230.
https://doi.org/10.1002/em.21827
PMID: 24243566
Cord blood biomarkers of vascular endothelial growth (VEGF and sFlt-1) and postnatal growth:
a preterm birth cohort study
Voller SB, Chock S, Ernst LM, Su E, Liu X, Farrow KN, Mestan KK
Early Hum Dev. 2014 Apr; 90(4): 195-200.
https://doi.org/10.1016/j.earlhumdev.2014.01.003
PMID: 24480606
Fetal growth restriction and pulmonary hypertension in premature infants with bronchopulmonary dysplasia
Check J, Gotteiner N, Liu X, Su E, Porta N, Steinhorn R, Mestan KK
J Perinatol. 2013 Jul; 33(7): 553-557.
https://doi.org/10.1038/jp.2012.164
PMID: 23328924
Pulmonary hypertension in bronchopulmonary dysplasia
Berkelhamer SK, Mestan KK, Steinhorn RH
Semin Perinatol. 2013 Apr; 37(2): 124-131.
https://doi.org/10.1053/j.semperi.2013.01.009
PMID: 23582967
Cord blood 8-isoprostane in the preterm infant
Mestan K, Matoba N, Arguelles L, Harvey C, Ernst LM, Farrow K, Wang X
Early Hum Dev. 2012 Aug; 88(8): 683-689.
https://doi.org/10.1016/j.earlhumdev.2012.02.002
PMID: 22425039
Fetal origins of neonatal lung disease: understanding the pathogenesis of bronchopulmonary dysplasia
Mestan KK, Steinhorn RH
Am J Physiol Lung Cell Mol Physiol. 2011 Dec; 301(6): L858-L859.
https://doi.org/10.1152/ajplung.00314.2011
PMID: 21964401
Genomic sequencing in clinical trials
Mestan KK, Ilkhanoff L, Mouli S, Lin S
J Transl Med. 2011 Dec; 9: 222-.
https://doi.org/10.1186/1479-5876-9-222
PMID: 22206293
Cord blood immune biomarkers in
small for gestational age births
Matoba N, Ouyang F, Mestan KKL, Porta NFM, Pearson CM, Ortiz KM, Bauchner HC, Zuckerman BS, Wang X
J Dev Orig Health Dis. 2011 Apr; 2(2): 89-98.
https://doi.org/10.1017/S2040174411000018
PMID: 25140923 ISSN: 2040-1744
Placental inflammatory response is associated with poor neonatal growth: preterm birth cohort study
Mestan K, Yu Y, Matoba N, Cerda S, Demmin B, Pearson C, Ortiz K, Wang X
Pediatrics. 2010 Apr; 125(4): e891-e898.
https://doi.org/10.1542/peds.2009-0313
PMID: 20308216
Maternal obesity, diabetes mellitus and cord blood biomarkers in large-for-gestational age infants
Mestan K, Ouyang F, Matoba N, Pearson C, Ortiz K, Wang X
Journal of Pediatric Biochemistry. 2010 Jan; 1(3): 217-224.
https://doi.org/10.1055/s-0036-1586378
ISSN: 1879-5390
Differential patterns of 27 cord blood immune biomarkers across gestational age
Matoba N, Yu Y, Mestan K, Pearson C, Ortiz K, Porta N, Thorsen P, Skogstrand K, Hougaard DM, Zuckerman B, Wang X
Pediatrics. 2009 May; 123(5): 1320-1328.
https://doi.org/10.1542/peds.2008-1222
PMID: 19403498
Cord blood biomarkers of
the fetal inflammatory response
Mestan K, Yu Y, Thorsen P, Skogstrand K, Matoba N, Liu X, Kumar R, Hougaard DM, Gupta M, Pearson C, Ortiz K, Bauchner H, Wang X
J Matern Fetal Neonatal Med. 2009 May; 22(5): 379-387.
https://doi.org/10.1080/14767050802609759
PMID: 19529994
The joint association between F5 gene polymorphisms and maternal smoking during pregnancy on preterm delivery
Yu Y, Tsai H-J, Liu X, Mestan K, Zhang S, Pearson C, Ortiz K, Xu X, Zuckerman B, Wang X
Hum Genet. 2009 Jan; 124(6): 659-668.
https://doi.org/10.1007/s00439-008-0589-2
PMID: 19020903
Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: new insights on GxE interactions and pathogenic pathways
Tsai H-J, Liu X, Mestan K, Yu Y, Zhang S, Fang Y, Pearson C, Ortiz K, Zuckerman B, Bauchner H, Cerda S, Stubblefield PG, Xu X, Wang X
Hum Genet. 2008 May; 123(4): 359-369.
https://doi.org/10.1007/s00439-008-0485-9
PMID: 18320229
Impact of clinical and histologic correlates of maternal and fetal inflammatory response on gestational age in preterm births
Gupta M, Mestan KK, Martin CR, Pearson C, Ortiz K, Fu L, Stubblefield P, Cerda S, Kasznica JM, Wang X
J Matern Fetal Neonatal Med. 2007 Jan; 20(1): 39-46.
https://doi.org/10.1080/14767050601156861
PMID: 17437198 ISSN: 1476-7058
Neurodevelopmental outcome of premature infants treated with inhaled nitric oxide
Mestan KKL, Marks JD, Hecox K, Huo D, Schreiber MD
N Engl J Med. 2005 Jul; 353(1): 23-32.
https://doi.org/10.1056/NEJMoa043514
PMID: 16000353
Nebulized sodium nitroprusside
Palhares D
J Pediatr. 2004 Oct; 145(4): 569-.
https://doi.org/10.1016/j.jpeds.2004.05.054
PMID: 15480393 ISSN: 0022-3476
Inhaled nitric oxide in premature infants with the respiratory distress syndrome: Commentary
Schreiber MD, Gin-Mestan K, Marks JD, Huo D, Lee G, Srisuparp P, Meau-Petit V
Archives de Pediatrie. 2004 Jan; 11(11): 1367-1368.
https://doi.org/10.1016/j.arcped.2004.09.001
ISSN: 0929-693X
Cardiopulmonary effects of nebulized sodium nitroprusside in term infants
with hypoxic respiratory failure
Mestan KKL, Carlson AD, White M, Powers JA, Morgan S, Meadow W, Schreiber MD
J Pediatr. 2003 Nov; 143(5): 640-643.
https://doi.org/10.1067/S0022-3476(03)00533-X
PMID: 14615737 ISSN: 0022-3476
Inhaled nitric oxide in premature infants
with the respiratory distress syndrome
Schreiber MD, Gin-Mestan K, Marks JD, Huo D, Lee G, Srisuparp P
N Engl J Med. 2003 Nov; 349(22): 2099-2107.
https://doi.org/10.1056/NEJMoa031154
PMID: 14645637