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Publications

Dr. Karen Mestan's PubMed

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Development of a novel humanized mouse model to study bronchopulmonary dysplasia

Birkett R, Newar J, Sharma AM, Lin E, Blank L, Swaminathan S, Misharin A, Mestan KK. Development of a novel humanized mouse model to study bronchopulmonary dysplasia. Front Pediatr. 2023 Jul 14;11:1146014.

doi: 10.3389/fped.2023.1146014.

PMID: 37520051

Leveraging the placenta to advance neonatal care

Mestan KK, Leibel SL, Sajti E, Pham B, Hietalati S, Laurent L and Parast M

Front. Pediatr. 2023 May; 11:1174174.

https://doi.org/10.3389/fped.2023.1174174

PMID: 37255571

Placental dysfunction influences fetal monocyte subpopulation gene expression in preterm birth

Sharma AM, Birkett R, Lin ET, Ernst LM, Grobman WA, Swaminathan S, Abdala-Valencia H, Misharin AV, Bartom ET, Mestan KK

JCI Insight. 2022 Jun; 7(11):

https://doi.org/10.1172/jci.insight.155482

PMID: 35471950

Moving the dial on prenatal stress mechanisms of neurodevelopmental vulnerability to mental health problems: A personalized prevention proof of concept

Wakschlag LS, Tandon D, Krogh-Jespersen S, Petitclerc A, Nielsen A, Ghaffari R, Mithal L, Bass M, Ward E, Berken J, Fareedi E, Cummings P, Mestan K, Norton ES, Grobman W, Rogers J, Moskowitz J, Alshurafa N

Dev Psychobiol. 2021 May; 63(4): 622-640.

https://doi.org/10.1002/dev.22057

PMID: 33225463

Understanding Racial Disparities of Preterm Birth Through the Placenta

Matoba N, Mestan KK, Collins JW

Clin Ther. 2021 Feb; 43(2): 287-296.

https://doi.org/10.1016/j.clinthera.2020.12.013

PMID: 33483135

Umbilical cord miRNAs to predict neonatal early onset sepsis

Ernst LM, Mithal LB, Mestan K, Wang V, Mangold KA, Freedman A, Das S

PLoS One. 2021; 16(5): e0249548-.

https://doi.org/10.1371/journal.pone.0249548

PMID: 33961620

Placental vascular maldevelopment, intrauterine growth restriction, and pulmonary hypertension

Mathias M, Bitar M, Aldulescu M, Birkett R, Perez M, Mestan K

Pulm Circ. 2020 Oct; 10(4): 2045894020970056-.

https://doi.org/10.1177/2045894020970056

PMID: 33282199 ISSN: 2045-8932

Soluble Klotho, a biomarker and therapeutic strategy to reduce bronchopulmonary dysplasia and pulmonary hypertension in preterm infants

Batlahally S, Franklin A, Damianos A, Huang J, Chen P, Sharma M, Duara J, Keerthy D, Zambrano R, Shehadeh LA, Martinez EC, DeFreitas MJ, Kulandavelu S, Abitbol CL, Freundlich M, Kanashiro-Takeuchi RM, Schmidt A, Benny M, Wu S, Mestan KK, Young KC

Sci Rep. 2020 Jul; 10(1): 12368-.

https://doi.org/10.1038/s41598-020-69296-1

PMID: 32704023

The impact of placental pathology discordance in multiple gestation pregnancies on bronchopulmonary dysplasia-associated pulmonary hypertension

Franklin A, Yallapragada S, Birkett R, Grobman W, Ernst LM, Mestan K

Pulm Circ. 2020 Jan; 10(1): 2045894020910674-.

https://doi.org/10.1177/2045894020910674

PMID: 32215199 ISSN: 2045-8932

Cord blood alpha klotho is decreased in small for gestational age preterm infants with placental lesions of accelerated aging

Franklin AD, Saqibuddin J, Stephens K, Birkett R, Marsden L, Ernst LM, Mestan KK

Placenta. 2019 Nov; 87: 1-7.

https://doi.org/10.1016/j.placenta.2019.08.088

PMID: 31499336

Racial differences in placental pathology
among very preterm births

Matoba N, Yallapragada S, Davis MM, Ernst LM, Collins JW, Mestan KK

Placenta. 2019 Aug; 83: 37-42.

https://doi.org/10.1016/j.placenta.2019.06.385

PMID: 31477205

Variations in Umbilical Cord Hematopoietic
and Mesenchymal Stem Cells
With Bronchopulmonary Dysplasia

Chaudhury S, Saqibuddin J, Birkett R, Falcon-Girard K, Kraus M, Ernst LM, Grobman W, Mestan KK

Front Pediatr. 2019; 7: 475-.

https://doi.org/10.3389/fped.2019.00475

PMID: 31799226 ISSN: 2296-2360

An update on the diagnosis and management
of bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension

Berkelhamer SK, Mestan KK, Steinhorn R

Semin Perinatol. 2018 Nov; 42(7): 432-443.

https://doi.org/10.1053/j.semperi.2018.09.005

PMID: 30384985

Umbilical cord blood metabolomics reveal distinct signatures of dyslipidemia prior to bronchopulmonary dysplasia and
pulmonary hypertension

La Frano MR, Fahrmann JF, Grapov D, Pedersen TL, Newman JW, Fiehn O, Underwood MA, Mestan K, Steinhorn RH, Wedgwood S

Am J Physiol Lung Cell Mol Physiol. 2018 Nov; 315(5): L870-L881.

https://doi.org/10.1152/ajplung.00283.2017

PMID: 30113229

Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy

Liu X, Hong X, Tsai H-J, Mestan KK, Shi M, Kefi A, Hao K, Chen Q, Wang G, Caruso D, Geng H, Gao Y, He J, Kumar R, Wang H, Yu Y, Bartell T, Tan X-D, Schleimer RP, Weeks DE, Pongracic JA, Wang X

Medicine (Baltimore). 2018 Mar; 97(9): e0043-.

https://doi.org/10.1097/MD.0000000000010043

PMID: 29489655

Vital signs analysis algorithm detects inflammatory response in premature infants with late onset sepsis and necrotizing enterocolitis

Mithal LB, Yogev R, Palac HL, Kaminsky D, Gur I, Mestan KK

Early Hum Dev. 2018 Feb; 117: 83-89.

https://doi.org/10.1016/j.earlhumdev.2018.01.008

PMID: 29351876

Fetal cord blood and tissue immune responses to chronic placental inflammation
and chorioamnionitis

Singh AM, Sherenian MG, Kim K-Y, Erickson KA, Yang A, Mestan K, Ernst LM, Kumar R

Allergy Asthma Clin Immunol. 2018; 14: 66-.

https://doi.org/10.1186/s13223-018-0297-y

PMID: 30473713 ISSN: 1710-1484

Cord Blood Biomarkers of Placental Maternal Vascular Underperfusion Predict Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension

Mestan KK, Gotteiner N, Porta N, Grobman W, Su EJ, Ernst LM

J Pediatr. 2017 Jun; 185: 33-41.

https://doi.org/10.1016/j.jpeds.2017.01.015

PMID: 28162769

Cord Blood Acute Phase Reactants Predict Early Onset Neonatal Sepsis in Preterm Infants

Mithal LB, Palac HL, Yogev R, Ernst LM, Mestan KK

PLoS One. 2017; 12(1): e0168677-.

https://doi.org/10.1371/journal.pone.0168677

PMID: 28045978

Computerized vital signs analysis and late onset infections in extremely low gestational age infants

Mithal LB, Yogev R, Palac H, Gur I, Mestan KK

J Perinat Med. 2016 Jul; 44(5): 491-497.

https://doi.org/10.1515/jpm-2015-0362

PMID: 26845716

Cord Blood Ferritin and Fibroblast Growth Factor-23 Levels in Neonates

Ali FN, Josefson J, Mendez AJ, Mestan K, Wolf M

J Clin Endocrinol Metab. 2016 Apr; 101(4): 1673-1679.

https://doi.org/10.1210/jc.2015-3709

PMID: 26859104

The placenta as a diagnostic tool
for the neonatologist

Yallapragada SG, Mestan KK, Ernst LM

NeoReviews. 2016 Mar; 17(3): e131-e143.

https://doi.org/10.1542/neo.17-3-e131

Placental Villous Vascularity Is Decreased in Premature Infants with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension

Yallapragada SG, Mestan KK, Palac H, Porta N, Gotteiner N, Hamvas A, Grobman W, Ernst LM

Pediatr Dev Pathol. 2016 Mar; 19(2): 101-107.

https://doi.org/10.2350/15-05-1646-OA.1

PMID: 26366786 ISSN: 1093-5266

Flow Cytometry Reveals Similarities
Between Lung Macrophages in Humans and Mice

Bharat A, Bhorade SM, Morales-Nebreda L, McQuattie-Pimentel AC, Soberanes S, Ridge K, DeCamp MM, Mestan KK, Perlman H, Budinger GRS, Misharin AV

Am J Respir Cell Mol Biol. 2016 Jan; 54(1): 147-149.

https://doi.org/10.1165/rcmb.2015-0147LE

PMID: 26274047

Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARNT)

Su EJ, Xin H, Yin P, Dyson M, Coon J, Farrow KN, Mestan KK, Ernst LM

Journal of Clinical Endocrinology and Metabolism. 2015 Jan; 100(1): E30-E40.

https://doi.org/10.1210/jc.2014-2385

PMID: 25343232 ISSN: 0021-972X

Response to "Letter to the editor: Angiogenesis factors in cord blood and post-natal growth failure: a biochemical evaluation"

Baehl Voller S, Mestan KK

Early Hum Dev. 2014 Sep; 90(9): 543-.

https://doi.org/10.1016/j.earlhumdev.2014.05.012

PMID: 24954697

Placental pathologic changes of maternal vascular underperfusion in bronchopulmonary dysplasia and pulmonary hypertension

Mestan KK, Check J, Minturn L, Yallapragada S, Farrow KN, Liu X, Su E, Porta N, Gotteiner N, Ernst LM

Placenta. 2014 Aug; 35(8): 570-574.

https://doi.org/10.1016/j.placenta.2014.05.003

PMID: 24906549

Maternal preconception body mass index and offspring cord blood DNA methylation: exploration of early life origins of disease

Liu X, Chen Q, Tsai H-J, Wang G, Hong X, Zhou Y, Zhang C, Liu C, Liu R, Wang H, Zhang S, Yu Y, Mestan KK, Pearson C, Otlans P, Zuckerman B, Wang X

Environ Mol Mutagen. 2014 Apr; 55(3): 223-230.

https://doi.org/10.1002/em.21827

PMID: 24243566

Cord blood biomarkers of vascular endothelial growth (VEGF and sFlt-1) and postnatal growth:
a preterm birth cohort study

Voller SB, Chock S, Ernst LM, Su E, Liu X, Farrow KN, Mestan KK

Early Hum Dev. 2014 Apr; 90(4): 195-200.

https://doi.org/10.1016/j.earlhumdev.2014.01.003

PMID: 24480606

Fetal growth restriction and pulmonary hypertension in premature infants with bronchopulmonary dysplasia

Check J, Gotteiner N, Liu X, Su E, Porta N, Steinhorn R, Mestan KK

J Perinatol. 2013 Jul; 33(7): 553-557.

https://doi.org/10.1038/jp.2012.164

PMID: 23328924

Pulmonary hypertension in
bronchopulmonary dysplasia

Berkelhamer SK, Mestan KK, Steinhorn RH

Semin Perinatol. 2013 Apr; 37(2): 124-131.

https://doi.org/10.1053/j.semperi.2013.01.009

PMID: 23582967

Cord blood 8-isoprostane in the preterm infant

Mestan K, Matoba N, Arguelles L, Harvey C, Ernst LM, Farrow K, Wang X

Early Hum Dev. 2012 Aug; 88(8): 683-689.

https://doi.org/10.1016/j.earlhumdev.2012.02.002

PMID: 22425039

Fetal origins of neonatal lung disease: understanding the pathogenesis of bronchopulmonary dysplasia

Mestan KK, Steinhorn RH

Am J Physiol Lung Cell Mol Physiol. 2011 Dec; 301(6): L858-L859.

https://doi.org/10.1152/ajplung.00314.2011

PMID: 21964401

Genomic sequencing in clinical trials

Mestan KK, Ilkhanoff L, Mouli S, Lin S

J Transl Med. 2011 Dec; 9: 222-.

https://doi.org/10.1186/1479-5876-9-222

PMID: 22206293

Cord blood immune biomarkers in
small for gestational age births

Matoba N, Ouyang F, Mestan KKL, Porta NFM, Pearson CM, Ortiz KM, Bauchner HC, Zuckerman BS, Wang X

J Dev Orig Health Dis. 2011 Apr; 2(2): 89-98.

https://doi.org/10.1017/S2040174411000018

PMID: 25140923 ISSN: 2040-1744

Placental inflammatory response is associated with poor neonatal growth: preterm birth cohort study

Mestan K, Yu Y, Matoba N, Cerda S, Demmin B, Pearson C, Ortiz K, Wang X

Pediatrics. 2010 Apr; 125(4): e891-e898.

https://doi.org/10.1542/peds.2009-0313

PMID: 20308216

Maternal obesity, diabetes mellitus and cord blood biomarkers in large-for-gestational age infants

Mestan K, Ouyang F, Matoba N, Pearson C, Ortiz K, Wang X

Journal of Pediatric Biochemistry. 2010 Jan; 1(3): 217-224.

https://doi.org/10.1055/s-0036-1586378

ISSN: 1879-5390

Differential patterns of 27 cord blood immune biomarkers across gestational age

Matoba N, Yu Y, Mestan K, Pearson C, Ortiz K, Porta N, Thorsen P, Skogstrand K, Hougaard DM, Zuckerman B, Wang X

Pediatrics. 2009 May; 123(5): 1320-1328.

https://doi.org/10.1542/peds.2008-1222

PMID: 19403498

Cord blood biomarkers of
the fetal inflammatory response

Mestan K, Yu Y, Thorsen P, Skogstrand K, Matoba N, Liu X, Kumar R, Hougaard DM, Gupta M, Pearson C, Ortiz K, Bauchner H, Wang X

J Matern Fetal Neonatal Med. 2009 May; 22(5): 379-387.

https://doi.org/10.1080/14767050802609759

PMID: 19529994

The joint association between F5 gene polymorphisms and maternal smoking during pregnancy on preterm delivery

Yu Y, Tsai H-J, Liu X, Mestan K, Zhang S, Pearson C, Ortiz K, Xu X, Zuckerman B, Wang X

Hum Genet. 2009 Jan; 124(6): 659-668.

https://doi.org/10.1007/s00439-008-0589-2

PMID: 19020903

Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: new insights on GxE interactions and pathogenic pathways

Tsai H-J, Liu X, Mestan K, Yu Y, Zhang S, Fang Y, Pearson C, Ortiz K, Zuckerman B, Bauchner H, Cerda S, Stubblefield PG, Xu X, Wang X

Hum Genet. 2008 May; 123(4): 359-369.

https://doi.org/10.1007/s00439-008-0485-9

PMID: 18320229

Impact of clinical and histologic correlates of maternal and fetal inflammatory response on gestational age in preterm births

Gupta M, Mestan KK, Martin CR, Pearson C, Ortiz K, Fu L, Stubblefield P, Cerda S, Kasznica JM, Wang X

J Matern Fetal Neonatal Med. 2007 Jan; 20(1): 39-46.

https://doi.org/10.1080/14767050601156861

PMID: 17437198 ISSN: 1476-7058

Inhaled nitric oxide

Lasser EC

N Engl J Med. 2005 Oct; 353(15): 1626-1628.

PMID: 16224823

Neurodevelopmental outcome of premature infants treated with inhaled nitric oxide

Mestan KKL, Marks JD, Hecox K, Huo D, Schreiber MD

N Engl J Med. 2005 Jul; 353(1): 23-32.

https://doi.org/10.1056/NEJMoa043514

PMID: 16000353

Nebulized sodium nitroprusside

Palhares D

J Pediatr. 2004 Oct; 145(4): 569-.

https://doi.org/10.1016/j.jpeds.2004.05.054

PMID: 15480393 ISSN: 0022-3476

Inhaled nitric oxide in premature infants with the respiratory distress syndrome: Commentary

Schreiber MD, Gin-Mestan K, Marks JD, Huo D, Lee G, Srisuparp P, Meau-Petit V

Archives de Pediatrie. 2004 Jan; 11(11): 1367-1368.

https://doi.org/10.1016/j.arcped.2004.09.001

ISSN: 0929-693X

Cardiopulmonary effects of nebulized sodium nitroprusside in term infants
with hypoxic respiratory failure

Mestan KKL, Carlson AD, White M, Powers JA, Morgan S, Meadow W, Schreiber MD

J Pediatr. 2003 Nov; 143(5): 640-643.

https://doi.org/10.1067/S0022-3476(03)00533-X

PMID: 14615737 ISSN: 0022-3476

Inhaled nitric oxide in premature infants
with the respiratory distress syndrome

Schreiber MD, Gin-Mestan K, Marks JD, Huo D, Lee G, Srisuparp P

N Engl J Med. 2003 Nov; 349(22): 2099-2107.

https://doi.org/10.1056/NEJMoa031154

PMID: 14645637

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